vitex agnus castus extract improves learning and memory and increases the transcription of estrogen receptor α in hippocampus of ovariectomized rats
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چکیده
introduction: lower level of estrogen hormone is considered as an important factor for loss of learning and memory in postmenopausal women. although estrogen replacement therapy is used for compensation, but long-term usage of estrogen is associated with a higher risk of hormonedependent cancers. phytoestrogens, due to fewer side effects, have been proposed to prevent menopause-related cognitive decline. methods: 24 female wistar rats weighing 180-220 g were used in this study. the animals were ovariectomized and randomly divided into four groups including, control and two groups which received 8 and 80 mg/kg vitex agnus castus (vac) ethanolic extract orally. the last groups were treated with 40 μg/kg of estradiol valerat. step-through passive avoidance (stpa) test was used for the evaluation of learning and memory. the hippocampal estrogen receptor α (erα) expression was measured using real-time pcr. results: the results demonstrated that vac extract or estradiol had better performance on stepthrough passive avoidance test than control group (all p<0.05). moreover, administration of either estradiol or vac extract increased the hippocampal mrna level of erα and prevented the decrease in uterine weight of ovariectomized rats. discussion: based on our data, vac extract improves learning and memory in ovariectomized rats. the positive effect of vac extract on learning and memory is possibly associated with an increase in erα gene expression in the hippocampal formation.
منابع مشابه
Vitex Agnus Castus Extract Improves Learning and Memory and Increases the Transcription of Estrogen Receptor α in Hippocampus of Ovariectomized Rats
Introduction: Lower level of estrogen hormone is considered as an important factor for loss of learning and memory in postmenopausal women. Although estrogen replacement therapy is used for compensation, but long-term usage of estrogen is associated with a higher risk of hormonedependent cancers. Phytoestrogens, due to fewer side effects, have been proposed to prevent menopause-related co...
متن کاملVitex Agnus Castus Extract Improves Learning and Memory and Increases the Transcription of Estrogen Receptor α in Hippocampus of Ovariectomized Rats
INTRODUCTION Lower level of estrogen hormone is considered as an important factor for loss of learning and memory in postmenopausal women. Although estrogen replacement therapy is used for compensation, but long-term usage of estrogen is associated with a higher risk of hormone-dependent cancers. Phytoestrogens, due to fewer side effects, have been proposed to prevent menopause-related cognitiv...
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Vitex agnus-castus (VAC) is a plant that has recently been used to treat the symptoms of menopause, by its actions on the central nervous system. However, little is known about its actions on disturbances in lipid metabolism and nonalcoholic fat liver disease (NAFLD), frequently associated with menopause. Ovariectomized (OVX) rats exhibit increased adiposity and NAFLD 13 weeks after ovary remov...
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عنوان ژورنال:
basic and clinical neuroscienceجلد ۶، شماره ۳، صفحات ۱۸۵-۱۹۲
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