vitex agnus castus extract improves learning and memory and increases the transcription of estrogen receptor α in hippocampus of ovariectomized rats

نویسندگان

mohammad allahtavakoli

najmeh honari

iran pourabolli

mohammad kazemi arababadi

چکیده

introduction: lower level of estrogen hormone is considered as an important factor for loss of learning and memory in postmenopausal women. although estrogen replacement therapy is used for compensation, but long-term usage of estrogen is associated with a higher risk of hormonedependent cancers. phytoestrogens, due to fewer side effects, have been proposed to prevent menopause-related cognitive decline. methods: 24 female wistar rats weighing 180-220 g were used in this study. the animals were ovariectomized and randomly divided into four groups including, control and two groups which received 8 and 80 mg/kg vitex agnus castus (vac) ethanolic extract orally. the last groups were treated with 40 μg/kg of estradiol valerat. step-through passive avoidance (stpa) test was used for the evaluation of learning and memory. the hippocampal estrogen receptor α (erα) expression was measured using real-time pcr. results: the results demonstrated that vac extract or estradiol had better performance on stepthrough passive avoidance test than control group (all p<0.05). moreover, administration of either estradiol or vac extract increased the hippocampal mrna level of erα and prevented the decrease in uterine weight of ovariectomized rats. discussion: based on our data, vac extract improves learning and memory in ovariectomized rats. the positive effect of vac extract on learning and memory is possibly associated with an increase in erα gene expression in the hippocampal formation.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Vitex Agnus Castus Extract Improves Learning and Memory and Increases the Transcription of Estrogen Receptor α in Hippocampus of Ovariectomized Rats

Introduction: Lower level of estrogen hormone is considered as an important factor for loss of learning and memory in postmenopausal women. Although estrogen replacement therapy is used for compensation, but long-term usage of estrogen is associated with a higher risk of hormonedependent cancers. Phytoestrogens, due to fewer side effects, have been proposed to prevent menopause-related co...

متن کامل

Vitex Agnus Castus Extract Improves Learning and Memory and Increases the Transcription of Estrogen Receptor α in Hippocampus of Ovariectomized Rats

INTRODUCTION Lower level of estrogen hormone is considered as an important factor for loss of learning and memory in postmenopausal women. Although estrogen replacement therapy is used for compensation, but long-term usage of estrogen is associated with a higher risk of hormone-dependent cancers. Phytoestrogens, due to fewer side effects, have been proposed to prevent menopause-related cognitiv...

متن کامل

Vitex agnus-castus L. (Verbenaceae) Improves the Liver Lipid Metabolism and Redox State of Ovariectomized Rats

Vitex agnus-castus (VAC) is a plant that has recently been used to treat the symptoms of menopause, by its actions on the central nervous system. However, little is known about its actions on disturbances in lipid metabolism and nonalcoholic fat liver disease (NAFLD), frequently associated with menopause. Ovariectomized (OVX) rats exhibit increased adiposity and NAFLD 13 weeks after ovary remov...

متن کامل

بررسی اثر عصاره گیاه پنج انگشت (Vitex agnus castus) بر یادگیری و حافظه در موش های صحرایی اوارکتومی شده

Background and purpose: Menopause is associated with the cessation of ovarian activities and hypoestrogenemia causing many complications including learning and memory disorders. Recent studies have shown that these cognitive disabilities are due to the diminished neuroprotective and neurotrophic effects of estrogen and accordingly, estrogen therapy may prevent or overcome them. Since estrogen t...

متن کامل

Vitex agnus-castus

Vitex agnus-castus has a long tradition as a herbal remedy and was used in ancient times not only as an anaphrodisiac and for preserving chastity but also against diverse disturbances of the female genital system. In actual clinical trials, the fruit Agni casti fructus was shown to relieve premenstrual syndrome (PMS) and especially breast swelling and pain, due to its dopaminergic effect. Altho...

متن کامل

Alecrim de Angola - Vitex Agnus-castus

Vitex agnus-castus L. (chaste-berry). Phytomedicine. 2004 Jan;11(1):18-23. Liu J, Burdette JE, Sun Y, Deng S, Schlecht SM, Zheng W, Nikolic D, Mahady G, van Breemen RB, Fong HH, Pezzuto JM, Bolton JL, Farnsworth NR. Department of Medicinal Chemistry and Pharmacognosy, UIC/NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illi...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
basic and clinical neuroscience

جلد ۶، شماره ۳، صفحات ۱۸۵-۱۹۲

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023